Searchable abstracts of presentations at key conferences in oncology

oa0001p015 | (1) | PacRim7

Combinatorial co-targeting by miRNAs: a subtle but strong regulator of epithelia-mesenchymal transitions

Cursons Joseph , Pillman Katherine A , Scheer Kaitlin G , Gregory Philip A , Foroutan Momeneh , Hediyeh-Zadeh Soroor , Toubia John , Crampin Edmund J , Goodall Gregory J , Bracken Cameron P , Davis Melissa J

Epithelial-mesenchymal transition (EMT) and the reverse mesenchymal-epithelial transition (MET) are normal biological processes, however they are also thought to play a critical role in the progression and metastasis of cancers, including breast cancer. Cancer cells reactivate the gene expression programs of EMT and MET through a wide range of mechanisms, and better understanding of these regulatory processes will lead to the identification of therapeutically actionable target...